欢迎来到“甜菊网”官方网站微信公众号|繁體中文
开启辅助访问
官方QQ群:
13232659
在线客服:
客服一
客服二
二维码
官网地址: www.stevia.com.cn
全站搜索桌面快捷方式去提建议钻石VIP会员充值叶子
 找回密码
 注册帐号

QQ登录

只需一步,快速开始

|订单中心 |购物车有0件商品
瑞鲍迪甙A对大鼠的致畸作用
(0 评价)792 阅读0 下载
龙源期刊网 http://www.qikan.com.cn 瑞鲍迪甙瑞鲍迪甙 A 对大鼠的致畸作用对大鼠的致畸作用 作者:王雨晶 来源:《安徽农业科学》2015 年第 05 期 摘要 [目的] 为进一步评价瑞鲍迪甙 A的安全性积累资料。[方法] 于大鼠孕 7~17 d 经口给 予 340、1 130和 3 400 mg/kg b.w. 剂量的瑞鲍迪甙 A,观察母鼠和仔鼠的生长发育情况,研究 瑞鲍迪甙 A对大鼠的生殖毒性和胚胎毒性。[结果]各剂量瑞鲍迪甙 A组孕鼠行为正常,无中毒 和死亡情况。各剂量瑞鲍迪甙 A组黄体数、着床数、活胎率、窝仔数及畸胎率、活胎仔畸形 率及母体畸胎率等与正常对照组均无显著差异(P>0.05)。[结论]瑞鲍迪甙 A对大鼠无明显生 殖毒性及胚胎毒性和致畸作用。 关键词 瑞鲍迪甙 A;致畸作用;Wistar大鼠 中图分类号 S859 文献标识码 A 文章编号 0517-6611(2015)05-131-02 Study on the Teratogenicity of Rebaudioside A in Wistar Rats WANG Yujing1, LU Qianqian1, YU Zhengrong1, ZHANG Yumei1,2* et al (1.College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009; 2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009) Abstract [Objective] The research aimed to provide materials for evaluating the safety of rebaudioside A futher. [Method] Rats were administrated with rebaudioside A at the doses of 340, 1 130 and 3 400 mg/kg b.w by gavage from the 7th day to the 17th day during the gestation. The growth and development laws of mother rats and baby rats were observed. And the reproductive toxicity and fetal toxicity of rebaudioside A to rats were studied. [Result] Abnormal behaviours, toxic symptom and death were not found on tested rats. And there was no significant difference of the luteal count, implanted number and live fetus rate, litter size, abnormal fetus rate, abnormal rate of live fetus and maternal teratogenic rate in the groups of different doses of rebaudioside A had no significant difference with that on control group(P>0.05) . [Conclusion] Rebaudioside A had no obvious reproductive toxicity, embryo toxicity and teratogenic effect on Wistar rats. Key words Rebaudioside A; Teratogenic effect; Wistar rats 基金项目 江苏高校优势学科建设工程资助项目;扬州大学“新世纪人才”工程资助项目。 作者简介

打分:

0 星

用户评论: